\s matches a single whitespace character using the character set [ \t\n\r\f\v].
Me Fail English?\nThat's\tUnpossible. <- match 1
Me Fail English?\nThat's\tUnpossible. <- match 2
Me Fail English?\nThat's\tUnpossible. <- match 3
Me Fail English?\nThat's\tUnpossible. <- match 4
Me Fail English?\nThat's\tUnpossible. <- match 5
\s+ matches one or more whitespace characters.
Me Fail English?\nThat's\tUnpossible. <- match 1
Me Fail English?\nThat's\tUnpossible. <- match 2
Me Fail English?\nThat's\tUnpossible. <- match 3
re.sub(pattern="\s+", repl=" ", string=quote) replaces each match with a single space.