The Simpsons Solution

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import re

newquote = re.sub(pattern="\s+", repl=" ", string=quote)

print(newquote)
# Me Fail English? That's Unpossible.

Explanation

1. \s matches a single whitespace character using the character set [ \t\n\r\f\v].

   Me Fail   English?\nThat's\tUnpossible.  <- match 1
   Me Fail   English?\nThat's\tUnpossible.  <- match 2
   Me Fail   English?\nThat's\tUnpossible.  <- match 3
   Me Fail   English?\nThat's\tUnpossible.  <- match 4
   Me Fail   English?\nThat's\tUnpossible.  <- match 5
   

2. \s+ matches one or more whitespace characters.

   Me Fail   English?\nThat's\tUnpossible.  <- match 1
   Me Fail   English?\nThat's\tUnpossible.  <- match 2
   Me Fail   English?\nThat's\tUnpossible.  <- match 3
   

3. re.sub(pattern="\s+", repl=" ", string=quote) replaces each match with a single space.

   Me Fail English? That's Unpossible.
   

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See the problem